Fat cells play a role in cognitive decline
The results released this week reveal new information about the role of fat cells in cognitive decline and neurodegeneration, according to a study involving the oxidant amplification loop led by scientists at Marshall University.
The research, published in iScience, shows that fat cells control the systemic response to brain function, causing impaired memory and cognition in mice. Activation of the Na, K-ATPase oxidative amplification loop affects the expression of important protein markers in fat cells as well as in the hippocampus, which can worsen brain function and lead to neurodegeneration. Targeting fat cells to oppose Na, K-ATPase may improve these results.
“We sought to demonstrate that Na, K-ATPase signaling, particularly in adipocytes, plays a central role in inducing alterations in specific regions of the brain, notably in the hippocampus, which is essential for memory and cognitive function, ”said senior author Joseph I Shapiro, MD, professor and dean of Marshall University’s Joan C. Edwards School of Medicine.
The researchers used a genetically engineered mouse model that released the NaKtide peptide specifically in adipocytes, or fat cells, to find that NaKtide inhibited the signaling function of Na, K-ATPase. Expression of adipocyte-specific NaKtide enhanced the altered adipocyte phenotype and improved function of the hippocampus, the part of the brain associated with memory and cognition. Induction of oxidative stress through a Western diet increased the production of inflammatory cytokines confined to adipocytes as well as altered protein markers of memory and cognition in the hippocampus.
“The Western diet induces oxidative stress and adipocyte alteration through Na, K-ATPase signaling which causes systemic inflammation and affects behavioral and brain biochemical changes,” said Komal Sodhi, MD, lead author and professor associate of surgery and biomedical sciences at the Joan C. Edwards School of Medicine. “Our study showed that the expression of adipocyte-specific NaKtide in our mouse model enhanced these changes and improved the neurodegenerative phenotype.”
Reference: Sodhi K, Pratt R, Wang X et al. Role of the oxidative amplification loop of Na, K-ATPase adipocytes in cognitive decline and neurodegeneration. iScience. 2021: 103262. doi: 10.1016 / j.isci.2021.103262
This article was republished from the following materials. Note: The material may have been modified for its length and content. For more information, please contact the cited source.